Global and regional trends

Of the estimated 39.0 million [confidence bounds: 33.0-45.7 million] people living with HIV worldwide in 2022, 2.58 million [1.91-3.47 million] were children aged 0-19. Each day in 2022, approximately 740 children became infected with HIV and approximately 274 children died from AIDS related causes, mostly because of inadequate access to HIV prevention, care and treatment services.

As of 2022, roughly 13.9 million [10.6-18.4 million] children under the age of 18 had lost one or both parents to AIDS-related causes. Millions more have been affected by the epidemic, through a heightened risk of poverty, homelessness, school dropout, discrimination and loss of opportunities, as well as COVID-19. These hardships include prolonged illness and death. Of the estimated 624,000 [466,000-890,000] people who died of AIDS-related illnesses in 2022, 990,000 [67,000-140,000] (or approximately 16 per cent) of them were children under 20 years of age.

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Global trends

In 2022, around 130,000 [90,000-210,000] children aged 0-9 were newly infected with HIV, bringing the total number of children aged 0-9 living with HIV to 930,000 [730,000-1.28 million]. Nearly 85 per cent of these children live in sub-Saharan Africa. One bright spot on the global horizon is the rapid decline of approximately 58 per cent in new HIV infections among children aged 0-9 since 2010 due to stepped-up efforts to prevent mother-to-child transmission of HIV. However, the number of new HIV infections among adolescents (aged 10-19) has declined at a slower rate of about 47 per cent.

An estimated 100,000 [67,000-146,000] children and adolescents died from AIDS-related causes in 2022. About 73 per cent of these preventable deaths occurred among children under 10 years old. The number of annual AIDS-related deaths among children has declined by about 80 per cent since its peak in 2002, while the number of annual AIDS-related deaths among those aged 10-19 has only decreased by 27 per cent since 2002.

Geographic disparity

Sub-Saharan Africa, particularly Southern Africa, remains the region most heavily affected by the epidemic. In 2022, sub-Saharan Africa accounted for approximately 66 per cent of people of all ages living with HIV and 85 per cent of children and adolescents living with HIV worldwide. The spread of HIV in sub-Saharan Africa is mostly through heterosexual relationships, both in the context of transactional and commercial sex and in longer-term relationships, including marriage. Current evidence in Southern Africa has identified sexual relationships between adolescent girls or young women and older men as a common HIV transmission route. In addition, infants born to mothers living with HIV are at risk of becoming infected if their mothers are not on effective treatment or retained in care.

In most other regions of the world, HIV disproportionately affects persons who inject drugs, men who have sex with men and sex workers. The epidemic is evolving, however, and transmission patterns are changing throughout the world. In Eastern Europe and Central Asia, HIV epidemics that were once distinguished largely by transmission among persons who inject drugs are now increasingly characterized by significant sexual transmission. In parts of Asia, HIV is transmitted more and more among heterosexual couples. In Asia as a whole, HIV epidemics have long been concentrated in persons who inject drugs, sex workers and their clients, and men who have sex with men. Now, HIV infections are steadily spreading into lower-risk populations through transmission to the sexual partners of those most at risk. For information on UNICEF’s programme and policy work, visit the Children & AIDS community of practice.

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